methoxetamine
Sign in to saveMethoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 451563566
- Drug.IUPAC_name
- (R/S)-2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone
- Drug.image
- Methoxetamine2DCSD.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 125px
- Drug.image2
- MXE.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200px
- Drug.legal_BR
- F2
- Drug.legal_UK
- Class B
- Drug.legal_US
- Schedule I
- Drug.legal_DE
- Anlage I
- Drug.legal_UN
- P II
- Drug.addiction_liability
- High
- Drug.class
- NMDA receptor antagonist; Dissociative hallucinogen; General anesthetic
- Drug.elimination_half life
- 3–6 hours
via Wikipedia infobox
Research
127 papers- Methoxetamine: A foe or friend?Neurochemistry international · 2019
- Methoxetamine--a novel recreational drug with potent hallucinogenic properties.Toxicology letters · 2014
- Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors.Journal of pharmacological sciences · 2022
- Methoxetamine Induces Cytotoxicity in H9c2 Cells: Possible Role of p21 Protein (Cdc42/Rac)-Activated Kinase 1.Cardiovascular toxicology · 2019
- Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects: a review of case reports and preclinical findings.Behavioural pharmacology · 2016
via PubMed
Article
27 sectionsContents
- Recreational use
- Effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Detection in body fluids
- History
- Society and culture
- Media coverage
- Legal status
- Brazil
- Canada
- China
- European Union
- Finland
- Israel
- Japan
- Poland
- Russia
- Sweden
- Switzerland
- United Kingdom
- United Nations
- United States
- References
- External links
Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.
MXE is an arylcyclohexylamine. It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.
Gallery (3)
Connections
Categories
3-Methoxyphenyl compoundsArylcyclohexylaminesChemical pages without DrugBank identifierDesigner drugsDissociative drugsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs not assigned an ATC codeDrugs with non-standard legal statusEuphoriantsKetonesNMDA receptor antagonists