minichromosome maintenance complex component 6
Sign in to saveAlso known as DNA replication licensing factor MCM6, minichromosome maintenance deficient (mis5, S. pombe) 6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe), p105MCM, MCM6
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication.
Protein · UniProt
DNA replication licensing factor MCM6
- Gene
- MCM6
- Organism
- Homo sapiens (Human)
- Length
- 821 aa
- Molecular mass
- 92,889 Da
- Evidence
- 1: Evidence at protein level
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of…
Swiss-Prot (reviewed) · via UniProt
Research
205 papers- Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma.Oncology reports · 2020
- Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma.Virchows Archiv : an international journal of pathology · 2018
- Plasma minichromosome maintenance complex component 6 is a novel biomarker for hepatocellular carcinoma patients.Hepatology research : the official journal of the Japan Society of Hepatology · 2014
- Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.The Journal of biological chemistry · 2008
- Correlation of Minichromosome Maintenance Protein 6 Expression Rate and Clinical Outcome in Patients With Hodgkin's Lymphoma.Acta medica Iranica · 2017
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- P352
- Ebikon
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Gene
- Interactions
- See also
- References
- Further reading
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication.
== Function ==
Excerpted from Wikipedia’s “minichromosome maintenance complex component 6” article, available under the CC BY-SA 4.0 licence.