MLXIPL

Also known as MIO, CHREBP, MONDOB, WBSCR14, WS-bHLH, bHLHd14, MLX interacting protein like, MLX

protein-coding gene in the species Homo sapiens

Gene data

MLXIPL

Name: MLX interacting protein like
Type: protein-coding
Position: 73,593,194–73,624,575 (−)
Aliases: CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14
Ensembl: ENSG00000009950
RefSeq RNA: NM_032951.3, NM_032952.3, NM_032953.3, NM_032954.3, NM_032994.2
RefSeq protein: NP_116569.1, NP_116570.1, NP_116571.1, NP_116572.1, XP_011514579.1

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter by glucose regulation of DNA-templated transcription regulation of transcription by RNA polymerase II positive regulation of cell population proliferation lipid biosynthetic process anatomical structure morphogenesis glucose mediated signaling pathway

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Insulin resistance - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Metabolism Metabolism PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity Integration of energy metabolism Integration of energy metabolism ChREBP activates metabolic gene expression

via MyGene.info

Gene · Ensembl

MLX interacting protein like

Symbol: MLXIPL
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:73,593,194-73,624,575
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 32507
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/51085
genetic association: lipid metabolism disorder
chromosome: human chromosome 7
genomic start: 73007524
genomic end: 73038873
cytogenetic location: 7q11.23

Sources (8)

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MLXIPL

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Wikidata facts

Available in 6 languages

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What links here822 pages