monoamine oxidase
Sign in to saveAlso known as amine:oxygen oxidoreductase (deaminating), MAO
class of enzymes
In the Vinony graph
Within Vinony's link graph, monoamine oxidase is referenced by 584 other articles, and connects out to mitochondrion, MAOA and flavin adenine dinucleotide.
It is catalogued under topics including Amphetamine, EC 1.4.3 and Genes on human chromosome X.
Its subject is documented across 30 Wikipedia language editions.
Key facts
- Ec no
- 1.4.3.4
- Cas no
- 9001-66-5
- Intenz
- IntEnz view
- Brenda
- BRENDA entry
- Expasy
- NiceZyme view
- Kegg
- KEGG entry
- Metacyc
- metabolic pathway
- Priam
- profile
- Pdb structures
- RCSB PDB PDBe PDBsum
- Gene ontology
- AmiGO / QuickGO
- Pmc
- articles
- Pubmed
- articles
- Ncbi
- proteins
via Wikipedia infobox
Research
26,208 papers- Monoamine Oxidase Interactions.Journal of clinical psychopharmacology · 2023
- MONOAMINE OXIDASE INHIBITORS.Anaesthesia · 1964
- Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies.European journal of medicinal chemistry · 2022
- Pharmacokinetics of monoamine oxidase B inhibitors in Parkinson's disease: current status.Expert opinion on drug metabolism & toxicology · 2019
- Monoamine oxidase inhibition.Biochemical Society transactions · 1994
via PubMed
Wikidata facts
- Image
- Monoamine oxidase A 2BXS.png
Show 2 more facts
- Commons category
- Monoamine oxidase
- EC enzyme number
- 1.4.3.4
via Wikidata · CC0
~12 min read
Encyclopedic overview
Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most cell types of the body. The first such enzyme was discovered in 1928 by Mary Bernheim in the liver and was named tyramine oxidase. The MAOs belong to the protein family of flavin-containing amine oxidoreductases.
MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.
Excerpted from Wikipedia’s “monoamine oxidase” article, available under the CC BY-SA 4.0 licence.