Structure via PubChem · Public domain (PubChem)
minaprine
Sign in to saveAlso known as CB-30038, AGR-1240, 4-methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin, 4-{2-[(4-Methyl-6-phenyl-3-pyridazinyl)amino]ethyl}morpholine, N-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.
Chemical data
- Formula
- C17H22N4O
- Molecular weight
- 298.4 g/mol
- IUPAC name
- 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
- SMILES
- CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
- InChIKey
- LDMWSLGGVTVJPG-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 50.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Research
131 papers- Cholinomimetic activities of minaprine.Naunyn-Schmiedeberg's archives of pharmacology · 1989
- [Minaprine].Revista de medicina de la Universidad de Navarra · 1984
- Minaprine, a new drug with antidepressant properties.Drugs under experimental and clinical research · 1985
- Novel aminopyridazine derivative of minaprine modified by radiolysis presents potent anti-inflammatory effects in LPS-stimulated RAW 264.7 and DH82 macrophage cells.Scientific reports · 2023
- Minaprine for senile dementia.Lancet (London, England) · 1985
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 298.179
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₇H₂₂N₄O
- World Health Organisation international non-proprietary name
- minaprine
- Commons category
- Minaprine
- canonical SMILES
- CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
- isomeric SMILES
- CC\1=CC(=NN/C1=N\CCN2CCOCC2)C3=CC=CC=C3
- defined daily dose
- 0.1
- subject has role
- antidepressant
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.
Excerpted from Wikipedia’s “minaprine” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 11 languages
via Wikidata sitelinks · CC0