morphine-6-glucuronide
Sign in to saveAlso known as M6G, morphine 6-glucuronide
Morphine-6-glucuronide (M6G) is a major active metabolite of morphine. M6G is formed from morphine by the enzyme UGT2B7. It has analgesic effects roughly half that of morphine. M6G can accumulate to toxic levels in kidney failure.
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- History of discovery
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Morphine-6-glucuronide (M6G) is a major active metabolite of morphine. M6G is formed from morphine by the enzyme UGT2B7. It has analgesic effects roughly half that of morphine. M6G can accumulate to toxic levels in kidney failure.
==History of discovery== This analgesic activity of M6G (in animals) was first noted by Yoshimura.
Excerpted from Wikipedia’s “morphine-6-glucuronide” article, available under the CC BY-SA 4.0 licence.