Structure via PubChem · Public domain (PubChem)
masitinib
Sign in to saveAlso known as AB-1010, AB1010, Masican® (proposed trade name), AB 1010
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumours in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. Masitinib has been studied for several human conditions including melanoma, multiple myeloma, gastrointestinal cancer, pancreatic cancer, Alzheimer's disease, multiple sclerosis, rheumatoid arthritis, mastocytosis, amyotrophic lateral sclerosis, and COVID-19.
In the Vinony graph
Vinony's link graph records 496 inbound references to masitinib, and connects out to mastocytosis, tyrosine-kinase inhibitor and KIT proto-oncogene, receptor tyrosine kinase.
It is catalogued under topics including 3-Pyridyl compounds, 4-Methylpiperazin-1-yl compounds and Chemical pages without DrugBank identifier.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C28H30N6OS
- Molecular weight
- 498.6 g/mol
- IUPAC name
- 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
- SMILES
- CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
- InChIKey
- WJEOLQLKVOPQFV-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 102 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- neoplasm, rheumatoid arthritis, chronic progressive multiple sclerosis, multiple myeloma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 498.220181
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₈H₃₀N₆OS
- canonical SMILES
- CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
- World Health Organisation international non-proprietary name
- masitinib
- Commons category
- Masitinib
via Wikidata · CC0
~4 min read
Encyclopedic overview
4 sectionsContents
- Mechanism of action
- Society and culture
- Legal status
- References
{{Drugbox | IUPAC_name = 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide | image = Masitinib structure.svg | image_class = skin-invert-image | width = 250
| tradename = Masivet, Kinavet | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_category = | routes_of_administration = | ATC_prefix = L01 | ATC_suffix = EX06 | ATC_supplemental =
Excerpted from Wikipedia’s “masitinib” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0