Structure via PubChem · Public domain (PubChem)
mupirocin
Also known as pseudomonic acid, 9-{(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)oxan-2-yl]-3-methylbut-2-enoyl}oxynonanoic acid, pseudomonic acid A, C26H44O9, BRL-4910A
Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis. It may also be used to get rid of methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms. Out of concerns of developing resistance, use for greater than ten days is not recommended. It is used as a cream or ointment applied to the skin.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 408766144
- Drug.image
- Mupirocin structure.png
- Drug.image_class
- skin-invert-image
- Drug.width
- 320
- Drug.alt
- Structural formula of pseudomonic acid A (PA-A), the principal component of mupirocin
- Drug.image2
- Mupirocin molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the pseudomonic acid A molecule, the principal component of mupirocin
- Drug.caption
- Pseudomonic acid A (PA-A), the principal component of mupirocin
- Drug.tradename
- Bactroban, others
- Drug.MedlinePlus
~12 min read
Article
9 sectionsContents
- Medical uses
- Resistance
- Mechanism of action
- Biosynthesis
- Biosynthesis of pseudomonic acid A
- Monic acid biosynthesis
- Post-PKS tailoring
- 9-Hydroxy-nonanoic acid biosynthesis
- References
Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis. It may also be used to get rid of methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms. Out of concerns of developing resistance, use for greater than ten days is not recommended. It is used as a cream or ointment applied to the skin.
Common side effects include itchiness and rash at the site of application, headache, and nausea. Long-term use may result in increased growth of fungi. Use during pregnancy and breastfeeding appears to be safe. Mupirocin is chemically a carboxylic acid. It works by blocking a bacterium's ability to make protein, which usually results in bacterial death.