N-acetylserotonin
Sign in to saveAlso known as O-demethylmelatonin, N-acetyl-5-hydroxytryptamine, NAS, N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide, N-Acetyl Serotonin
'''N-Acetylserotonin (NAS), also known as normelatonin''', is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.
Research
873 papers- Neuroprotective Effects of N-acetylserotonin and Its Derivative.Neuroscience · 2023
- N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.Cell cycle (Georgetown, Tex.) · 2022
- N-Acetylserotonin in the central nervous system.Progress in neuro-psychopharmacology & biological psychiatry · 1984
- N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats.International journal of ophthalmology · 2024
- N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012
via PubMed
~4 min read
Encyclopedic overview
8 sectionsContents
- Biological function
- TrkB receptor
- Antioxidant properties
- Anti-inflammatory effects
- Miscellaneous
- Biochemistry
- See also
- References
'''N-Acetylserotonin (NAS), also known as normelatonin', is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.
==Biological function== Like melatonin, NAS is an agonist at the melatonin receptors MT1, MT2, and MT3, and may be considered to be a neurotransmitter. In addition, NAS is distributed in some areas of the brain where serotonin and melatonin are not, suggesting that it may have unique central duties of its own instead of merely functioning as a precursor in the synthesis of melatonin. NAS is known to have anti-depressant, neurotrophic and cognition-enhancing effects and has been proposed to be a target for the treatment of aging-associated cognitive decline and depression
Excerpted from Wikipedia’s “N-acetylserotonin” article, available under the CC BY-SA 4.0 licence.