NEUROG2

Also known as Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

In the Vinony graph

Within Vinony's link graph, NEUROG2 is referenced by 816 other articles, and connects out to PubMed, human chromosome 4 and homeobox.

It sits within the topics Genes on human chromosome 4 and Human proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

NEUROG2

Name: neurogenin 2
Type: protein-coding
Position: 112,513,516–112,516,180 (−)
Aliases: Atoh4, Math4A, NGN2, bHLHa8, ngn-2
Ensembl: ENSG00000178403
RefSeq RNA: NM_024019.4
RefSeq protein: NP_076924.1

This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012].

Gene Ontology

Biological process

sensory organ development forebrain development positive regulation of transcription by RNA polymerase II axon development

Molecular function

DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific protein binding protein dimerization activity E-box binding E-box binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus

Pathways

Dopaminergic Neurogenesis

via MyGene.info

Gene · Ensembl

neurogenin 2

Symbol: NEUROG2
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:112,513,516-112,516,180
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 7633
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/63973
genomic end: 112516180
genomic start: 113434672
chromosome: human chromosome 4
cytogenetic location: 4q25
expressed in: anterior cingulate cortex

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.

Excerpted from Wikipedia’s “NEUROG2” article, available under the CC BY-SA 4.0 licence.