RARA
Sign in to saveAlso known as NR1B1, RAR, retinoic acid receptor alpha, RARalpha
protein-coding gene in the species Homo sapiens
Gene data
RARA- Name
- retinoic acid receptor alpha
- Type
- protein-coding
- Position
- 40,309,165–40,357,643 (+)
- Aliases
- NR1B1, RAR, RARalpha
- Ensembl
- ENSG00000131759
- RefSeq RNA
- NM_000964.4, NM_001024809.4, NM_001033603.1, NM_001145301.3, NM_001145302.3
- RefSeq protein
- NP_000955.1, NP_001019980.1, NP_001138773.1, NP_001138774.1, XP_005257609.1
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
mRNA regulatory element binding translation repressor activitytranscription cis-regulatory region bindingRNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II transcription regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA-binding transcription factor activity, RNA polymerase II-specific
Pathways
Th17 cell differentiation - Homo sapiens (human)Estrogen signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Acute myeloid leukemia - Homo sapiens (human)Developmental BiologyDevelopmental BiologySignal TransductionGeneric Transcription PathwaySUMOylation
via MyGene.info
Gene · Ensembl
retinoic acid receptor alpha
- Symbol
- RARA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:40,309,165-40,357,643
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein RARA PDB 1dkf.png
Show 8 more facts
- HomoloGene ID
- 20262
- exact match
- identifiers.org/ncbigene/5914
- found in taxon
- Homo sapiens
- genomic end
- 38513094
- genomic start
- 40309180
- chromosome
- human chromosome 17
- cytogenetic location
- 17q21.2
- expressed in
- canal of the cervix
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