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GeneQ18031040· pop 12· linked from 948 articles

RARA

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Also known as NR1B1, RAR, retinoic acid receptor alpha, RARalpha

protein-coding gene in the species Homo sapiens

Gene data

RARA

Name: retinoic acid receptor alpha
Type: protein-coding
Position: 40,309,180–40,357,643 (+)
Aliases: NR1B1, RAR, RARalpha
Ensembl: ENSG00000131759
RefSeq RNA: NM_000964.4, NM_001024809.4, NM_001033603.1, NM_001145301.3, NM_001145302.3
RefSeq protein: NP_000955.1, NP_001019980.1, NP_001138773.1, NP_001138774.1, XP_005257609.1

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II liver development regulation of DNA-templated transcription protein phosphorylation germ cell development female pregnancy positive regulation of cell population proliferation negative regulation of cell population proliferation

Molecular function

mRNA regulatory element binding translation repressor activity transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Th17 cell differentiation - Homo sapiens (human)Estrogen signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Acute myeloid leukemia - Homo sapiens (human)Developmental Biology Developmental Biology Signal Transduction Generic Transcription Pathway SUMOylation

via MyGene.info

Wikidata facts

Image: Protein RARA PDB 1dkf.png

Show 5 more facts

HomoloGene ID: 20262
exact match: identifiers.org/ncbigene/5914
genomic end: 38513094
genomic start: 40309180
cytogenetic location: 17q21.2

Sources (6)

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Categories

Genes on human chromosome 17 Intracellular receptors Transcription factors