neurogranin
Sign in to saveAlso known as ng, neurogranin (protein kinase C substrate, RC3), NRGN, calmodulin-binding protein, protein kinase C substrate, RC3
Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin has recently been found in aortic endothelial cells and cardiomyocytes. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones.<!--
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Within Vinony's link graph, neurogranin is referenced by 36 other articles, and connects out to PubMed, Online Mendelian Inheritance in Man and UniProt.
It is catalogued under topics including Genes on human chromosome 11 and Protein pages needing a picture.
Its subject is documented across 5 Wikipedia language editions.
Protein · UniProt
Neurogranin
- Gene
- NRGN
- Organism
- Homo sapiens (Human)
- Length
- 78 aa
- Molecular mass
- 7,618 Da
- Evidence
- 1: Evidence at protein level
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)
Swiss-Prot (reviewed) · via UniProt
Research
771 papers- Neurogranin: A Potential Biomarker of Neurological and Mental Diseases.Frontiers in aging neuroscience · 2020
- Neurogranin Regulates Metaplasticity.Frontiers in molecular neuroscience · 2019
- Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.Redox biology · 2024
- Neurogranin facilitates maintaining the immunosuppressive state of hepatocellular carcinoma by promoting TGF-β1 secretion.International journal of biological macromolecules · 2025
- Neurogranin regulates calcium-dependent cardiac hypertrophy.Experimental and molecular pathology · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- cytosol
- found in taxon
- Homo sapiens
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Neurogranin is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin has recently been found in aortic endothelial cells and cardiomyocytes. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones. Human neurogranin consists of 78 amino acids.
One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males, another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.
Excerpted from Wikipedia’s “neurogranin” article, available under the CC BY-SA 4.0 licence.