Structure via PubChem · Public domain (PubChem)
nifedipine
Sign in to saveAlso known as Adalat®, BAY-A-1040, Procardia®, Adipine, 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester, Nifedipino, Nifecor, Adapine
Nifedipine ( ), sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother to a well-qualified medical facility before delivery. It is a calcium channel blocker of the dihydropyridine type. Nifedipine is taken by mouth
Chemical data
- Formula
- C17H18N2O6
- Molecular weight
- 346.3 g/mol
- IUPAC name
- dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
- InChIKey
- HYIMSNHJOBLJNT-UHFFFAOYSA-N
- XLogP
- 2.2
- Polar surface area
- 110 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- alkaloid
- Has part
- carbon
- Mass
- 346.116486
- Image
- Nifedipine substance photo.jpg
- Has use
- medication
Show 12 more facts
- Commons category
- Nifedipine
- chemical formula
- C₁₇H₁₈N₂O₆
- legal status (medicine)
- boxed warning
- medical condition treated
- angina pectoris
- canonical SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
- World Health Organisation international non-proprietary name
- nifedipine
- subject has role
- essential medicine
- MCN code
- 2933.39.43
- found in taxon
- Homo sapiens
- stylized name
- NIFEdipine
- defined daily dose
- 30
- significant drug interaction
- cimetidine
via Wikidata · CC0
~8 min read
Encyclopedic overview
11 sectionsContents
- Medical uses
- High blood pressure
- Early labor
- Other
- Side effects
- Overdose
- Mechanism of action
- History
- Society and culture
- Brand names
- References
Nifedipine ( ), sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother to a well-qualified medical facility before delivery. It is a calcium channel blocker of the dihydropyridine type. Nifedipine is taken by mouth and comes in fast- and slow-release formulations.
Common side effects include lightheadedness, headache, feeling tired, leg swelling, cough, and shortness of breath. Serious side effects may include low blood pressure and heart failure. Nifedipine is considered safe in pregnancy and breastfeeding.
Excerpted from Wikipedia’s “nifedipine” article, available under the CC BY-SA 4.0 licence.