Structure via PubChem · Public domain (PubChem)
azimilide
Sign in to saveAzimilide is a class ΙΙΙ antiarrhythmic drug (used to control abnormal heart rhythms). The agents from this heterogeneous group have an effect on the repolarization, they prolong the duration of the action potential and the refractory period. Also they slow down the spontaneous discharge frequency of automatic pacemakers by depressing the slope of diastolic depolarization. They shift the threshold towards zero or hyperpolarize the membrane potential. Although each agent has its own properties and will have thus a different function.
Chemical data
- Formula
- C23H28ClN5O3
- Molecular weight
- 458 g/mol
- IUPAC name
- 1-[(E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione
- SMILES
- CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)/N=C/C3=CC=C(O3)C4=CC=C(C=C4)Cl
- InChIKey
- MREBEPTUUMTTIA-PCLIKHOPSA-N
- XLogP
- 3.2
- Polar surface area
- 72.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- congestive heart failure
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 457.188067
Show 4 more facts
- chemical formula
- C₂₃H₂₈ClN₅O₃
- canonical SMILES
- CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)N=CC3=CC=C(O3)C4=CC=C(C=C4)Cl
- isomeric SMILES
- CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)/N=C/C3=CC=C(O3)C4=CC=C(C=C4)Cl
- subject has role
- calcium channel blocker
Sources (1)
via Wikidata · CC0
~6 min read
Encyclopedic overview
5 sectionsContents
- Heart potential
- The ion currents
- Pharmacology
- Pharmacokinetics
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 458966843 | IUPAC_name = 1-({(E)-[5-(4-chlorophenyl)furan-2-yl]methylidene}amino)-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione | image = Azimilide.svg | image_class = skin-invert-image
| tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
Excerpted from Wikipedia’s “azimilide” article, available under the CC BY-SA 4.0 licence.