devapamil
Sign in to saveAlso known as 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((m-methoxyphenethyl)methylamino)valeronitrile, 5-(N-(3-methoxyphenethyl)-N-methylamino)-2-isopropyl-2-(3,4-dimethoxyphenyl)pentanenitrile
Devapamil is a calcium channel blocker. It is also known as desmethoxyverapamil, which is a phenylalkylamine (PAA) derivative. Devapamil not only inhibits by blocking the calcium gated channels, but also by depolarizing the membrane during the sodium-potassium exchanges.
Research
35 papers- The devapamil-binding site of the purified skeletal muscle receptor for organic-calcium channel blockers is modulated by micromolar and millimolar concentrations of Ca2+.European journal of biochemistry · 1991
- The effect of the phenylalkylamine D888 (devapamil) on force and Ca2+ current in isolated frog skeletal muscle fibres.The Journal of physiology · 1989
- Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site.Biophysical journal · 1997
- Structural model for phenylalkylamine binding to L-type calcium channels.The Journal of biological chemistry · 2009
- Extra- and intracellular action of quaternary devapamil on muscle L-type Ca(2+)-channels.British journal of pharmacology · 1996
via PubMed
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Encyclopedic overview
3 sectionsContents
- Structure
- Animal studies
- References
Devapamil is a calcium channel blocker. It is also known as desmethoxyverapamil, which is a phenylalkylamine (PAA) derivative. Devapamil not only inhibits by blocking the calcium gated channels, but also by depolarizing the membrane during the sodium-potassium exchanges.
== Structure == Devapamil consists of two aromatic rings with methoxy substituents connected by an alkylamine chain increasing flexibility and overall potency.
Excerpted from Wikipedia’s “devapamil” article, available under the CC BY-SA 4.0 licence.