lacidipine

Also known as GR-43659X

Lacidipine (tradenames Lacipil or Motens) is a calcium channel blocker. It is available as tablets containing 2 or 4 mg.

In the Vinony graph

Within Vinony's link graph, lacidipine is referenced by 323 other articles, and connects out to valproic acid, (RS)-baclofen and voltage-gated sodium channel.

It sits within the topics Alkene derivatives, Carboxylate esters and Chemical pages without DrugBank identifier.

Its subject is documented across 12 Wikipedia language editions.

Chemical data

Formula: C26H33NO6
Molecular weight: 455.5 g/mol
IUPAC name: diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C)C
InChIKey: GKQPCPXONLDCMU-CCEZHUSRSA-N
XLogP: 4.5
Polar surface area: 90.9 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: cardiovascular disease, hypertension, angina pectoris

via ChEMBL · EBI

Wikidata facts

Mass: 455.230788
Has use: medication

Show 8 more facts

chemical formula: C₂₆H₃₃NO₆
defined daily dose: 4
World Health Organisation international non-proprietary name: lacidipine
canonical SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C
isomeric SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C)C
subject has role: calcium channel blocker
Commons category: Lacidipine
significant drug interaction: droperidol

Sources (5)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
External links

{{Drugbox | Watchedfields = changed | verifiedrevid = 444433756 | IUPAC_name = Diethyl 4-{o-[(E)-2-tert-butoxycarbonylethenyl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | image = Lacidipine structure.svg | image_class = skin-invert-image | width = 240px

Excerpted from Wikipedia’s “lacidipine” article, available under the CC BY-SA 4.0 licence.