NISCH
Sign in to saveAlso known as I-1, IR1, IRAS, hIRAS, nischarin
Nischarin is a protein that in humans is encoded by the NISCH gene.
Gene data
NISCH- Name
- nischarin
- Type
- protein-coding
- Aliases
- I-1, IR1, IRAS, hIRAS
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 130564
- exact match
- identifiers.org/ncbigene/11188
- genomic end
- 52493068
- genomic start
- 52489134
- cytogenetic location
- 3p21.1
Sources (4)
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Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Nischarin is a protein that in humans is encoded by the NISCH gene.
== Function == This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane as well as early and recycling endosome membranes. It is a scaffold protein related to Sorting nexins and it regulates protein cargo traffic. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.