ニトラゼパム

Also known as Mogadon, Ro-45360, Ro-53059, Sonebon, 2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one, 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, Paxisyn, Unisomnia

睡眠薬の一つ

In the Vinony graph

Vinony's link graph records 798 inbound references to ニトラゼパム, and connects out to barbiturates, benzodiazepine drug and pharmacokinetics.

It sits within the topics Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and ECHA InfoCard ID from Wikidata.

Vinony links it to 29 Wikipedia language editions.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 461743504
Drug.IUPAC_name: 7-nitro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
Drug.image: Nitrazepam.svg
Drug.image_class: skin-invert-image
Drug.width: 222
Drug.image2: Nitrazepam-from-xtal-3D-balls.png
Drug.image_class2: bg-transparent
Drug.tradename: Alodorm, Apodorm, Arem, Cerson, Insoma, Insomin, Mogadon, Nitrados, Nitrazadon, Nitrosun, Nitravet, Ormodon, Paxadorm, Remnos, Epam, and Somnite
Drug.dependency_liability: Physical: High Psychological: Moderate
Drug.addiction_liability: Moderate
Drug.pregnancy_US: D
Drug.legal_BR: B1
Drug.legal_CA: Schedule IV
Drug.legal_AU: Schedule 4
Drug.legal_DE: Rx-only/Anlage III
Drug.legal_UN: Psychotropic Schedule IV

via Wikipedia infobox

Chemical data

Formula: C15H11N3O3
Molecular weight: 281.27 g/mol
IUPAC name: 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3
InChIKey: KJONHKAYOJNZEC-UHFFFAOYSA-N
XLogP: 2.2
Polar surface area: 87.3 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
Indications: epilepsy, anxiety, Dementia, depressive disorder

via ChEMBL · EBI

Research

1,342 papers

Clinical pharmacokinetics of nitrazepam.Clinical pharmacokinetics · 1981
[Clonazepam, nitrazepam, diazepam].Nihon rinsho. Japanese journal of clinical medicine · 1995
Nitrazepam (Mogadon) dependence.The British journal of psychiatry : the journal of mental science · 1975
[Benzodiazepine (clonazepam, nitrazepam, diazepam)].Nihon rinsho. Japanese journal of clinical medicine · 2004
Nitrazepam nightmares.British medical journal · 1973

via PubMed

Wikidata facts

Subclass of: alkaloid
Mass: 281.08
Has use: medication

Show 7 more facts

canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3
World Health Organisation international non-proprietary name: nitrazepam
Commons category: Nitrazepam
MCN code: 2933.91.62
significant drug interaction: loxapine
chemical formula: C₁₅H₁₁N₃O₃
defined daily dose: 5

Sources (4)

via Wikidata · CC0

Article · 日本語

ニトラゼパム（Nitrazepam）は、ベンゾジアゼピン系の中間型作用時間を持つ睡眠薬である。習慣性医薬品指定。日本では、1967年に商品名ベンザリン (Benzarin) として塩野義製薬が開発・発売し、またネルボン (Nelbon) として第一三共が販売している。連用により依存症、急激な量の減少により離脱症状を生じることがある。向精神薬に関する条約のスケジュールIVに指定されている。麻薬及び向精神薬取締法の第三種向精神薬である。

Abstract from DBpedia / Wikipedia · CC BY-SA