Structure via PubChem · Public domain (PubChem)
loxapine
Sign in to saveAlso known as Adasuve®, CL-62362, CL-71563, Loxapac®, Loxitane®, SUM-3170, Loxapina, Cloxazepine
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia and bipolar disorder. It is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.
In the Vinony graph
Within Vinony's link graph, loxapine is referenced by 2,713 other articles, and connects out to propranolol, fluphenazine and zuclopenthixol.
Vinony files it under 4-Methylpiperazin-1-yl compounds, Alpha-1 blockers and Alpha-2 blockers.
Its subject is documented across 21 Wikipedia language editions.
Key facts
- Drug.UNII
- LER583670J
- Drug.KEGG
- D02340
- Drug.ChEBI
- 50841
- Drug.ChEMBL
- 831
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 408581688
- Drug.image
- Loxapine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Loxapine ball-and-stick model from xtal 1977.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Loxitane, Adasuve
- Drug.MedlinePlus
- a682311
- Drug.licence_EU
- yes
- Drug.DailyMedID
- Loxapine
- Drug.licence_US
- Loxapine
via Wikipedia infobox
Chemical data
- Formula
- C18H18ClN3O
- Molecular weight
- 327.8 g/mol
- IUPAC name
- 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
- SMILES
- CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
- InChIKey
- XJGVXQDUIWGIRW-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 28.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
892 papersvia PubMed
Wikidata facts
- Mass
- 327.114
Show 3 more facts
- chemical formula
- C₁₈H₁₈ClN₃O
- Commons category
- Loxapine
- canonical SMILES
- CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Available forms
- Side effects
- Pharmacology
- Mechanism of action
- Use as an inhaled agitation medication
- Pharmacokinetics
- Chemistry
- References
- External links
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia and bipolar disorder. It is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.
Loxapine may be metabolized by N-demethylation to amoxapine, a tricyclic antidepressant.
Excerpted from Wikipedia’s “loxapine” article, available under the CC BY-SA 4.0 licence.