Structure via PubChem · Public domain (PubChem)
نوربرمید
Sign in to saveNorbormide (Raticate, Shoxin) is a toxic compound used as a rodenticide. It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
Chemical data
- Formula
- C33H25N3O3
- Molecular weight
- 511.6 g/mol
- IUPAC name
- 8-(hydroxy-phenyl-pyridin-2-ylmethyl)-10-[phenyl(pyridin-2-yl)methylidene]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
- SMILES
- C1=CC=C(C=C1)C(=C2C3C=C(C2C4C3C(=O)NC4=O)C(C5=CC=CC=C5)(C6=CC=CC=N6)O)C7=CC=CC=N7
- InChIKey
- DNTHHIVFNQZZRD-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 92.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
41 papers- The Enigma of Norbormide, a Rattus-Selective Toxicant.Cells · 2024
- Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries.Cardiovascular drug reviews · 2001
- Norbormide-Based Probes and Their Application for Mitochondrial Imaging in Drosophila Melanogaster.Methods in molecular biology (Clifton, N.J.) · 2021
- Distribution of the vasoconstrictor and vasorelaxant effects of norbormide along the vascular tree of the rat.Life sciences · 2004
- The Selective Rat Toxicant Norbormide Blocks K(ATP) Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells.Frontiers in pharmacology · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 511.18959166
Show 3 more facts
- canonical SMILES
- OC(C1=CC2C3C(C1\C2=C(/C1=CC=CC=C1)C1=CC=CC=N1)C(=O)NC3=O)(C1=CC=CC=C1)C1=NC=CC=C1
- chemical formula
- C₃₃H₂₅N₃O₃
- subject has role
- rodenticide
Sources (2)
via Wikidata · CC0