norbormide
Sign in to saveNorbormide (Raticate, Shoxin) is a toxic compound used as a rodenticide. It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
Research
41 papers- The Enigma of Norbormide, a Rattus-Selective Toxicant.Cells · 2024
- Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries.Cardiovascular drug reviews · 2001
- Norbormide-Based Probes and Their Application for Mitochondrial Imaging in Drosophila Melanogaster.Methods in molecular biology (Clifton, N.J.) · 2021
- Distribution of the vasoconstrictor and vasorelaxant effects of norbormide along the vascular tree of the rat.Life sciences · 2004
- The Selective Rat Toxicant Norbormide Blocks K(ATP) Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells.Frontiers in pharmacology · 2019
via PubMed
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Encyclopedic overview
17 sectionsContents
- History
- Structure and reactivity
- Synthesis
- Available forms
- Different stereoisomers
- Derivatives
- Mechanism of action
- Metabolism
- In vitro experiment
- In vivo experiment
- Adverse effects & effects on animals
- Adverse effects
- Effects on animals
- Toxicity
- Acute toxicity studies in rats
- Toxicity studies in mammals and birds
- References
Norbormide (Raticate, Shoxin) is a toxic compound used as a rodenticide. It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.
Excerpted from Wikipedia’s “norbormide” article, available under the CC BY-SA 4.0 licence.