NR0B1

Also known as AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG

DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that in humans is encoded by the NR0B1 gene (nuclear receptor subfamily 0, group B, member 1). The NR0B1 gene is located on the short (p) arm of the X chromosome between bands Xp21.3 and Xp21.2, from base pair 30,082,120 to base pair 30,087,136.

In the Vinony graph

Vinony's link graph records 827 inbound references to NR0B1, and connects out to Q180686, X chromosome and Sex determining region Y.

Vinony files it under Genes on human chromosome X and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

NR0B1

Name: nuclear receptor subfamily 0 group B member 1
Type: protein-coding
Chromosome: X
Position: 30,304,206–30,309,394 (−)
Aliases: AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2
Ensembl: ENSG00000169297
RefSeq RNA: NM_000475.5
RefSeq protein: NP_000466.2

This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008].