Structure via PubChem · Public domain (PubChem)
OSU-6162
Sign in to saveOSU-6162, also known as PNU-96391, is a compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely related drug pridopidine, and has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies. Both enantiomers show similar activity but with different ratios of effects, with the (S) enantiomer (–)-OSU-6162 that is more commonly used in research, having higher binding affinity to D2 but is a weaker partial agonist at 5-HT2A, while the (R) enantiomer (+)-OSU-6162 has higher eff
Chemical data
- Formula
- C15H23NO2S
- Molecular weight
- 281.4 g/mol
- IUPAC name
- (3S)-3-(3-methylsulfonylphenyl)-1-propylpiperidine
- SMILES
- CCCN1CCC[C@H](C1)C2=CC(=CC=C2)S(=O)(=O)C
- InChIKey
- GZVBVBMMNFIXGE-CQSZACIVSA-N
- XLogP
- 2.6
- Polar surface area
- 45.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 281.14495
Show 3 more facts
- isomeric SMILES
- CCCN1CCC[C@H](C1)C2=CC(=CC=C2)S(=O)(=O)C
- chemical formula
- C₁₅H₂₃NO₂S
- canonical SMILES
- CCCN1CCCC(C1)C2=CC(=CC=C2)S(=O)(=O)C
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
OSU-6162, also known as PNU-96391, is a compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely related drug pridopidine, and has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies. Both enantiomers show similar activity but with different ratios of effects, with the (S) enantiomer (–)-OSU-6162 that is more commonly used in research, having higher binding affinity to D2 but is a weaker partial agonist at 5-HT2A, while the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT2A but lower D2 affinity.
== See also == List of investigational hallucinogens and entactogens List of investigational Parkinson's disease drugs Non-hallucinogenic 5-HT2A receptor agonist 3-Phenylpiperidine Flumexadol LPH-5 PF-219,061
Excerpted from Wikipedia’s “OSU-6162” article, available under the CC BY-SA 4.0 licence.