Structure via PubChem · Public domain (PubChem)
otenabant
Sign in to saveAlso known as CP-945,598, CP-945598
Otenabant (CP-945,598) is a drug that acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.
Chemical data
- Formula
- C25H25Cl2N7O
- Molecular weight
- 510.4 g/mol
- IUPAC name
- 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide
- SMILES
- CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N
- InChIKey
- UNAZAADNBYXMIV-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 102 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- obesity
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 509.15
Show 3 more facts
- Commons category
- Otenabant
- canonical SMILES
- CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N
- chemical formula
- C₂₅H₂₅Cl₂N₇O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Otenabant (CP-945,598) is a drug that acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.
==See also== Cannabinoid receptor antagonist
Excerpted from Wikipedia’s “otenabant” article, available under the CC BY-SA 4.0 licence.