Structure via PubChem · Public domain (PubChem)
mefenorex
Sign in to saveMefenorex (marketed as Rondimen, Pondinil, Anexate) is an amphetamine derivative with a relatively mild psychostimulant profile. Developed in the 1960s, it was used throughout the 1970s as an appetite suppressant for treating obesity. Mefenorex is a prodrug of amphetamine; upon ingestion, the compound will begin to metabolize into, as well as promote the production of, the active metabolites levoamphetamine and dextroamphetamine. Multiple sources have noted the substance as exerting "mild stimulant effects....[and having] relatively little abuse potential."
Chemical data
- Formula
- C12H18ClN
- Molecular weight
- 211.73 g/mol
- IUPAC name
- N-(3-chloropropyl)-1-phenylpropan-2-amine
- SMILES
- CC(CC1=CC=CC=C1)NCCCCl
- InChIKey
- XXVROGAVTTXONC-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 12 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- obesity
via ChEMBL · EBI
Research
23 papers- Mefenorex (Rondimen).Drug and alcohol dependence · 1986
- Effect of mefenorex on 5-HT release: studies in vitro on rat hypothalamic slices and in vivo by microdialysis.Pharmacology, biochemistry, and behavior · 1995
- Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine.Drug metabolism reviews · 2000
- [Studies on the identification of psychotropic substances. VIII. Preparation and various analytical data of reference standard of some stimulants, amfepramone, cathinone, N-ethylamphetamine, fenethylline, fenproporex and mefenorex].Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences · 1992
- Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.Therapeutic drug monitoring · 2002
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 211.112777
Show 4 more facts
- chemical formula
- C₁₂H₁₈ClN
- canonical SMILES
- CC(CC1=CC=CC=C1)NCCCCl
- Commons category
- Mefenorex
- subject has role
- sympathomimetic drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Mefenorex (marketed as Rondimen, Pondinil, Anexate) is an amphetamine derivative with a relatively mild psychostimulant profile. Developed in the 1960s, it was used throughout the 1970s as an appetite suppressant for treating obesity. Mefenorex is a prodrug of amphetamine; upon ingestion, the compound will begin to metabolize into, as well as promote the production of, the active metabolites levoamphetamine and dextroamphetamine. Multiple sources have noted the substance as exerting "mild stimulant effects....[and having] relatively little abuse potential."
== References ==
Excerpted from Wikipedia’s “mefenorex” article, available under the CC BY-SA 4.0 licence.