羥可酮

Also known as dihydroxycodeinone, dihydrohydroxycodeinone, dihydro-14-hydroxycodeinone, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one, (-)-14-hydroxydihydrocodeinone, 4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one, Oxycontin

Oxycodone, sold under the brand names Endone and OxyContin (which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain. It is a highly addictive and commonly abused drug. It is usually taken orally, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetam

OverviewAI-generated

Oxycodone is a chemical compound with the formula C₁₈H₂₁NO₄. It was discovered in 1916. The substance has a mass of 315.147 and a weight of 315.4. Its IUPAC name is (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

The compound has a defined daily dose of 75. It carries a charge of 0, with an xlogp of 1.2 and a topological polar surface area of 59. Oxycodone features one hydrogen bond donor and five hydrogen bond acceptors. Stylized names for the substance include "oxyCODONE" and "OxyCONTIN".

Oxycodone is referenced by 1,646 other encyclopedia articles. A PubMed query for oxycodone returns a count of 6,111 entries.

Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Drug.C: 18
Drug.H: 21
Drug.N: 1
Drug.O: 4
Drug.verifiedrevid: 464196835
Drug.image: Oxycodone.svg
Drug.image_class: skin-invert-image
Drug.width: 183
Drug.image2: Oxycodone molecule ball.png
Drug.image_class2: bg-transparent
Drug.width2: 225
Drug.tradename: Roxicodone, OxyContin, Endone, others
Drug.MedlinePlus: a682132
Drug.DailyMedID: Oxycodone
Drug.pregnancy_AU: C
Drug.dependency_liability: High
Drug.addiction_liability: High
Drug.routes_of_administration: By mouth, sublingual, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural

via Wikipedia infobox

Chemical data

Formula: C18H21NO4
Molecular weight: 315.4 g/mol
IUPAC name: (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O
InChIKey: BRUQQQPBMZOVGD-XFKAJCMBSA-N
XLogP: 1.2
Polar surface area: 59 Å²
H-bond donors: 1
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

6,111 papers

via PubMed

Wikidata facts

Has part: carbon
Mass: 315.147
Has use: medication

Show 13 more facts

Commons category: Oxycodone
chemical formula: C₁₈H₂₁NO₄
World Health Organisation international non-proprietary name: oxycodone
medical condition treated: injury
isomeric SMILES: CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O
canonical SMILES: CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O
subject has role: essential medicine
time of discovery or invention: 1916-00-00
found in taxon: Papaver somniferum
stylized name: OxyCONTIN
defined daily dose: 30
legal status (medicine): boxed warning
significant drug interaction: primidone

Sources (7)

via Wikidata · CC0

Article · 中文

羟考酮是一种用于緩解疼痛的口服鴉片類藥物，于1916年首次在德国制成。它具有高度成瘾性，因此容易被滥用。服用藥物後該藥在十五分钟内就能開始缓解疼痛，藥效可以持续六個小时。該藥常见的副作用有欣快、便秘、恶心、呕吐、食欲不振、嗜睡、頭暈、瘙痒、口乾和出汗。严重的副作用可能包括上瘾、物質依賴、物質濫用、易怒、抑鬱、狂躁、譫妄、幻觉、換氣不足、心跳过缓和低血壓。

Abstract from DBpedia / Wikipedia · CC BY-SA