Gene data
PDK4- Name
- pyruvate dehydrogenase kinase 4
- Type
- protein-coding
- Position
- 95,583,497–95,597,638 (−)
- Ensembl
- ENSG00000004799
- RefSeq RNA
- NM_002612.4
- RefSeq protein
- NP_002603.1
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
protein kinase activityprotein kinase activityprotein kinase activitypyruvate dehydrogenase (acetyl-transferring) kinase activitypyruvate dehydrogenase (acetyl-transferring) kinase activitypyruvate dehydrogenase (acetyl-transferring) kinase activitypyruvate dehydrogenase (acetyl-transferring) kinase activityprotein binding
Pathways
Diabetic cardiomyopathy - Homo sapiens (human)Aerobic respiration and respiratory electron transportMetabolismSignal TransductionRegulation of pyruvate dehydrogenase (PDH) complexEpigenetic regulation of gene expressionSignaling by Retinoic AcidPyruvate metabolismGene expression (Transcription)Signaling by Nuclear Receptors
via MyGene.info
Gene · Ensembl
pyruvate dehydrogenase kinase 4
- Symbol
- PDK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:95,583,497-95,597,638
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PDK4 PDB 2E0A.png
Show 8 more facts
- HomoloGene ID
- 129720
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5166
- genomic end
- 95596516
- genomic start
- 95212811
- chromosome
- human chromosome 7
- cytogenetic location
- 7q21.3
- expressed in
- tibialis anterior muscle
via Wikidata · CC0