PPARA

Name

peroxisome proliferator activated receptor alpha

Type

protein-coding

Position

46,149,924–46,243,755 (+)

Aliases

NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR

Ensembl

ENSG00000186951

RefSeq RNA

NM_001001928.4, NM_001001929.3, NM_001001930.2, NM_001362872.2, NM_001362873.3

RefSeq protein

NP_001001928.1, NP_001001929.1, NP_001349801.1, NP_001349802.1, NP_001380870.1

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image

Protein PPARA PDB 1i7g.png

via Wikidata · CC0