pentoxifylline

Key facts

Drug.pregnancy_AU

B1

Drug.Watchedfields

changed

Drug.verifiedrevid

464198476

Drug.IUPAC_name

3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione

Drug.image

Pentoxifylline.svg

Drug.image_class

skin-invert-image

Drug.width

180

Drug.image2

Pentoxifylline xtal 2005 ball-and-stick.png

Drug.image_class2

bg-transparent

Drug.width2

200

Drug.tradename

Trental, many other names worldwide

Drug.MedlinePlus

a685027

Drug.licence_US

Pentoxifylline

Drug.pregnancy_US

C

Drug.legal_AU

S4

Drug.legal_CA

Rx-only

Drug.legal_UK

POM

Drug.legal_US

Rx-only

via Wikipedia infobox

Chemical data

Formula

C13H18N4O3

Molecular weight

278.31 g/mol

IUPAC name

3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

SMILES

CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C

InChIKey

BYPFEZZEUUWMEJ-UHFFFAOYSA-N

XLogP

0.3

Polar surface area

75.5 Ų

H-bond donors

0

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1984

Admin. routes

oral

Indications

chronic kidney disease, non-small cell lung carcinoma, cutaneous Leishmaniasis, endometriosis

via ChEMBL · EBI

• Pentoxifylline in dermatology.Journal of cosmetic dermatology · 2023
• Pentoxifylline for intermittent claudication.The Cochrane database of systematic reviews · 2020
• Pentoxifylline.Journal of the American Academy of Dermatology · 1994
• Pentoxifylline review.Journal of the American Podiatric Medical Association · 1987
• Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients.Pharmacology research & perspectives · 2020

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

278.138

Has use

medication

via Wikidata · CC0