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Structure via PubChem · Public domain (PubChem)
sch-442416
Sign in to saveAlso known as SCH 442416, SCH-442,416, SCH442,416
SCH-442,416 is a highly selective adenosine A2a subtype receptor antagonist. It is widely used in its 11C radiolabelled form to map the distribution of A2a receptors in the brain, where they are mainly found in the striatum, nucleus accumbens, and olfactory tubercle. Given its distribution in the brain, A2a receptors have been investigated for the treatment of various neurological disorders, and SCH-442,416 has shown promise in treatment of depression, Parkinson's disease, and catalepsy.
In the Vinony graph
Vinony's link graph records 188 inbound references to sch-442416, and connects out to adenosine receptor, diquafosol and copper.
It sits within the topics 2-Furyl compounds, 4-Methoxyphenyl compounds and Adenosine receptor antagonists.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C20H19N7O2
- Molecular weight
- 389.4 g/mol
- IUPAC name
- 4-(furan-2-yl)-10-[3-(4-methoxyphenyl)propyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
- SMILES
- COC1=CC=C(C=C1)CCCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5
- InChIKey
- AEULVFLPCJOBCE-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 109 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 389.160023
Show 2 more facts
- chemical formula
- C₂₀H₁₉N₇O₂
- canonical SMILES
- COC1=CC=C(C=C1)CCCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
SCH-442,416 is a highly selective adenosine A2a subtype receptor antagonist. It is widely used in its 11C radiolabelled form to map the distribution of A2a receptors in the brain, where they are mainly found in the striatum, nucleus accumbens, and olfactory tubercle. Given its distribution in the brain, A2a receptors have been investigated for the treatment of various neurological disorders, and SCH-442,416 has shown promise in treatment of depression, Parkinson's disease, and catalepsy.
== References ==
Excerpted from Wikipedia’s “sch-442416” article, available under the CC BY-SA 4.0 licence.