Structure via PubChem · Public domain (PubChem)
phaclofen
Sign in to savePhaclofen, or phosphonobaclofen, is a selective antagonist for the GABAB receptor. It was the first selective GABAB antagonist discovered, but its utility was limited by the fact that it does not cross the blood brain barrier.
Chemical data
- Formula
- C9H13ClNO3P
- Molecular weight
- 249.63 g/mol
- IUPAC name
- [3-amino-2-(4-chlorophenyl)propyl]phosphonic acid
- SMILES
- C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl
- InChIKey
- VSGNGLJPOGUDON-UHFFFAOYSA-N
- XLogP
- -2.4
- Polar surface area
- 83.6 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 249.032158
Show 2 more facts
- chemical formula
- C₉H₁₃ClNO₃P
- canonical SMILES
- C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Phaclofen, or phosphonobaclofen, is a selective antagonist for the GABAB receptor. It was the first selective GABAB antagonist discovered, but its utility was limited by the fact that it does not cross the blood brain barrier.
==References==
Excerpted from Wikipedia’s “phaclofen” article, available under the CC BY-SA 4.0 licence.