Structure via PubChem · Public domain (PubChem)
flurothyl
Sign in to saveAlso known as Indoklon, SK&F-6539, Flurotyl, HFE-356mff2
Flurothyl (formerly under the trade name Indoklon) (IUPAC names: 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane or bis(2,2,2-trifluoroethyl) ether) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether and sevoflurane, but having the opposite effects, acting as a stimulant and convulsant. A clear and stable liquid, it has a mild ethereal odor whose vapors are non-flammable. It is excreted from the body by the lungs in an unchanged state.
Chemical data
- Formula
- C4H4F6O
- Molecular weight
- 182.06 g/mol
- IUPAC name
- 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane
- SMILES
- C(C(F)(F)F)OCC(F)(F)F
- InChIKey
- KGPPDNUWZNWPSI-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 9.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
481 papers- Flurothyl Inhalation Therapy: Resurrecting an Alternative to Electricity Induced Seizures.The journal of ECT · 2024
- A flurothyl-induced seizure does not disrupt hippocampal memory reconsolidation in C57BL/6 J mice.Epilepsy research · 2022
- The chemical induction of seizures in psychiatric therapy: were flurothyl (indoklon) and pentylenetetrazol (metrazol) abandoned prematurely?Journal of clinical psychopharmacology · 2014
- Neocortical and cerebellar malformations affect flurothyl-induced seizures in female C57BL/6J mice.Frontiers in neuroscience · 2023
- The Repeated Flurothyl Seizure Model in Mice.Bio-protocol · 2017
via PubMed
Wikidata facts
- Subclass of
- per- and polyfluoroalkyl substances
- Mass
- 182.017
- Has use
- medication
Show 4 more facts
- chemical formula
- C₄H₄F₆O
- canonical SMILES
- C(C(F)(F)F)OCC(F)(F)F
- Commons category
- Flurothyl
- global warming potential
- 20
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
4 sectionsContents
- Research into psychiatric treatment
- Mechanism of action
- See also
- References
Flurothyl (formerly under the trade name Indoklon) (IUPAC names: 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane or bis(2,2,2-trifluoroethyl) ether) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether and sevoflurane, but having the opposite effects, acting as a stimulant and convulsant. A clear and stable liquid, it has a mild ethereal odor whose vapors are non-flammable. It is excreted from the body by the lungs in an unchanged state.
Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.
Excerpted from Wikipedia’s “flurothyl” article, available under the CC BY-SA 4.0 licence.