phenylsilatrane
Sign in to savePhenylsilatrane is a convulsant chemical which has been used as a rodenticide. Phenylsilatrane and some of its analogs with 4-substituents of H, CH3, Cl, Br, and CSi(CH3)3 are highly toxic to mice. They have been observed in the laboratory to inhibit the 35S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.
Wikidata facts
- Mass
- 251.09777
Show 4 more facts
- melting point
- 211
- chemical formula
- C₁₂H₁₇NO₃Si
- canonical SMILES
- C1CO[Si-]23([N+]1(CCO2)CCO3)C4=CC=CC=C4
- Commons category
- Phenyl silatrane
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Encyclopedic overview
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Phenylsilatrane is a convulsant chemical which has been used as a rodenticide. Phenylsilatrane and some of its analogs with 4-substituents of H, CH3, Cl, Br, and CSi(CH3)3 are highly toxic to mice. They have been observed in the laboratory to inhibit the 35S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.
== See also == Atrane GABAA receptor negative allosteric modulator GABAA receptor § Ligands Chlorophenylsilatrane
Excerpted from Wikipedia’s “phenylsilatrane” article, available under the CC BY-SA 4.0 licence.
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