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phenylthiourea
Sign in to saveAlso known as PTC, PhNHC(S)NH2, monophenyl thiourea, PhNHCSNH2, PhNHC(=S)NH2, alpha-phenylthiourea, phenyl-2-thiourea, phenylthiocarbamide
Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring.
Chemical data
- Formula
- C7H8N2S
- Molecular weight
- 152.22 g/mol
- IUPAC name
- phenylthiourea
- SMILES
- C1=CC=C(C=C1)NC(=S)N
- InChIKey
- FULZLIGZKMKICU-UHFFFAOYSA-N
- XLogP
- 0.7
- Polar surface area
- 70.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
1,417 papers- Phenylthiourea.Lancet (London, England) · 1972
- Phenylthiourea Binding to Human Tyrosinase-Related Protein 1.International journal of molecular sciences · 2020
- Phenylthiourea-Conjugated BODIPY as an Efficient Photosensitizer for Tyrosinase-Positive Melanoma-Targeted Photodynamic Therapy.ACS applied bio materials · 2021
- Development of phenylthiourea derivatives as allosteric inhibitors of pyoverdine maturation enzyme PvdP tyrosinase.Bioorganic & medicinal chemistry letters · 2020
- The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase.Journal of enzyme inhibition and medicinal chemistry · 2012
via PubMed
~6 min read
Encyclopedic overview
8 sectionsContents
- History
- Role in taste
- Genetics
- Non-taster phenotype distribution in selected populations
- Notes
- See also
- References
- External links
Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring.
It has the unusual property that it either tastes very bitter or is virtually tasteless, depending on the genetic makeup of the taster. The ability to taste PTC is often treated as a dominant genetic trait, although inheritance and expression of this trait are somewhat more complex.
Excerpted from Wikipedia’s “phenylthiourea” article, available under the CC BY-SA 4.0 licence.