TAS2R38
Sign in to saveAlso known as PTC, T2R38, T2R61, taste 2 receptor member 38, THIOT
Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.
Gene data
TAS2R38- Name
- taste 2 receptor member 38
- Type
- protein-coding
- Aliases
- PTC, T2R38, T2R61, THIOT
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009].
via MyGene.info
Gene · Ensembl
taste 2 receptor member 38
- Symbol
- TAS2R38
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:141,972,631-141,973,773
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~9 min read
Encyclopedic overview
12 sectionsContents
- Signal transduction
- Ligands
- Tissue distribution
- Clinical significance
- PTC sensitivity
- PROP sensitivity
- Drug consumption
- Pathogen resistance
- See also
- References
- Further reading
- External links
Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.
== Signal transduction ==
Excerpted from Wikipedia’s “TAS2R38” article, available under the CC BY-SA 4.0 licence.