Phosphofructokinase, platelet
Sign in to saveAlso known as PFK-C, 6-phosphofructokinase, platelet type, phosphohexokinase, 6-phosphofructokinase type C, PFKP, phosphofructo-1-kinase isozyme C, ATP-dependent 6-phosphofructokinase, platelet type, phosphofructokinase 1
Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.
Protein · UniProt
ATP-dependent 6-phosphofructokinase, platelet type
- Gene
- PFKP
- Organism
- Homo sapiens (Human)
- Length
- 784 aa
- Molecular mass
- 85,596 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
Swiss-Prot (reviewed) · via UniProt
Research
201 papers- Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth.Cell death & disease · 2022
- Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer.Oncology reports · 2022
- Phosphofructokinase Platelet Overexpression Accelerated Colorectal Cancer Cell Growth and Motility.Journal of Cancer · 2023
- Selective activation of PFKL suppresses the phagocytic oxidative burst.Cell · 2021
- Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion.Genes & genomics · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- extracellular exosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactive pathway map
- References
- Further reading
- External links
Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.
== Function ==
Excerpted from Wikipedia’s “Phosphofructokinase, platelet” article, available under the CC BY-SA 4.0 licence.