PIP4K2C

Also known as PIP5K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma is an enzyme in humans that is encoded by the PIP4K2C gene. It is one of the phosphatidylinositol 4-phosphate 5-kinases.

In the Vinony graph

Vinony's link graph records 3 inbound references to PIP4K2C, and connects out to human chromosome 12, Ensembl genome database project and list of EC numbers (EC 2).

It sits within the topics EC 2.7.1 and Genes on human chromosome 12.

Vinony links it to 6 Wikipedia language editions.

Gene data

PIP4K2C

Name: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Type: protein-coding
Position: 57,591,161–57,603,418 (+)
Aliases: PIP5K2C
Ensembl: ENSG00000166908
RefSeq RNA: NM_001146258.2, NM_001146259.2, NM_001146260.2, NM_024779.5, XM_005269152.4
RefSeq protein: NP_001139730.1, NP_001139731.1, NP_001139732.1, NP_079055.3, XP_005269209.1

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of autophagy phosphatidylinositol metabolic process negative regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphate biosynthetic process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process positive regulation of autophagosome assembly

Molecular function

protein binding 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity identical protein binding phosphatidylinositol kinase activity

Cellular component

cytoplasm cytoplasm autophagosome autophagosome endoplasmic reticulum endoplasmic reticulum cytosol cytosol

Pathways

Inositol phosphate metabolism - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)PIP3 activates AKT signaling Metabolism PI Metabolism Phospholipid metabolism Signal Transduction Synthesis of PIPs at the plasma membrane Negative regulation of the PI3K/AKT network

via MyGene.info

Gene · Ensembl

phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Symbol: PIP4K2C
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:57,591,161-57,603,418
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 23484
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79837
genomic end: 57997198
genomic start: 57984957
chromosome: human chromosome 12
cytogenetic location: 12q13.3
expressed in: islet of Langerhans

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
External links

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma is an enzyme in humans that is encoded by the PIP4K2C gene. It is one of the phosphatidylinositol 4-phosphate 5-kinases.

== References ==

Excerpted from Wikipedia’s “PIP4K2C” article, available under the CC BY-SA 4.0 licence.