piperacillin
Sign in to savePiperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. The chemical structure of piperacillin and other ureidopenicillins incorporates a polar side chain that enhances penetration into Gram-negative bacteria and reduces susceptibility to cleavage by Gram-negative beta lactamase enzymes. These properties confer activity against the important hospital pathogen Pseudomonas aeruginosa. Thus piperacillin is sometimes referred to as an "anti-pseudomonal penicillin".
Key facts
- Drug.verifiedrevid
- 461746289
- Drug.image
- Piperacillin skeletal formula labelled.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Piperacillin-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Pipracil
- Drug.pregnancy_AU
- B1
- Drug.pregnancy_US
- B
- Drug.routes_of_administration
- Intravenous (IV), intramuscular (IM)
- Drug.class
- β-lactam antibiotic
- Drug.ATC_prefix
- J01
- Drug.ATC_suffix
- CA12
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- 0% oral
- Drug.protein_bound
- 30%
- Drug.metabolism
- Largely not metabolized
- Drug.elimination_half life
- 36–72 minutes
via Wikipedia infobox
Article
12 sectionsContents
- Medical uses
- Pneumonia
- Administration
- Adverse effects
- Interactions
- Pharmacology
- Mechanism of action
- Mechanisms of resistance
- Pharmacokinetics
- Pharmacodynamics
- Chemistry
- References
{{Infobox drug | verifiedrevid = 461746289 | drug_name = | INN = | type = | image = Piperacillin skeletal formula labelled.svg | image_class = skin-invert-image | width = | alt = | caption = | image2 = Piperacillin-from-xtal-3D-bs-17.png | image_class2 = bg-transparent | pronounce = | tradename = Pipracil | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = | licence_US = | pregnancy_AU = B1 | pregnancy_AU_comment = | pregnancy_US = B | pregnancy_US_comment = | pregnancy_category = | dependency_liability = | addiction_liability = | routes_of_administration = Intravenous (IV), intramuscular (IM) | class = β-lactam antibiotic | ATC_prefix = J01 | ATC_suffix = CA12 | ATC_supplemental = | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_CA_comment = | legal_DE = | legal_DE_comment = | legal_NZ = | legal_NZ_comment = | legal_UK = POM | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = | legal_EU = | legal_EU_comment = | legal_UN = | legal_UN_comment = | legal_status =
| bioavailability = 0% oral | protein_bound = 30% | metabolism = Largely not metabolized | metabolites = | onset = | elimination_half-life = 36–72 minutes | duration_of_action = | excretion = 20% in bile, 80% unchanged in urine