chlorquinaldol

Also known as 5,7-dichloro-2-methyl-8-hydroxyquinoline, 5,7-dichloro-2-methyl-8-quinolinol, 2-methyl-5,7-dichloro-8-hydroxyquinoline, 5,7-dichloro-8-hydroxy-2-methylquinoline, 5,7-dichloro-8-quinaldinol, 5,7-dichloro-8-hydroxyquinaldine

Chlorquinaldol is an antimicrobial agent and antiseptic. It is a chlorinated derivative of the popular chelating agent 8-hydroxyquinoline. It is applied topically as a cream and internally as a losenge.

In the Vinony graph

Vinony's link graph records 146 inbound references to chlorquinaldol, and connects out to infection, oxyquinoline and silver.

Vinony files it under Antiprotozoal agents, Antiseptics and Chembox image size set.

Vinony links it to 16 Wikipedia language editions.

Chemical data

Formula: C10H7Cl2NO
Molecular weight: 228.07 g/mol
IUPAC name: 5,7-dichloro-2-methylquinolin-8-ol
SMILES: CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
InChIKey: GPTXWRGISTZRIO-UHFFFAOYSA-N
XLogP: 3.5
Polar surface area: 33.1 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: amebiasis

via ChEMBL · EBI

Research

145 papers

Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase.ACS central science · 2024
Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity.Pharmacological research · 2020
Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm-related antimicrobial cross-resistance.Infection and drug resistance · 2019
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice.Chemico-biological interactions · 2022
Antimycotic effect of chlorquinaldol.Transactions of the New York Academy of Sciences · 1955

via PubMed

Wikidata facts

Mass: 226.99

Show 8 more facts

route of administration: intravaginal administration
chemical formula: C₁₀H₇Cl₂NO
canonical SMILES: CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
World Health Organisation international non-proprietary name: chlorquinaldol
Commons category: Chlorquinaldol
defined daily dose: 0.2
subject has role: bactericide
medical condition treated: vaginitis