MCR-1
Sign in to savethumb|right|Escherichia coli|E. coli, the bacterium in which MCR-1 was first identified. The mobilized colistin resistance (mcr) gene confers plasmid-mediated resistance to colistin, one of a number of last-resort antibiotics for treating Gram-negative infections. mcr-1, the original variant, is capable of horizontal transfer between different strains of a bacterial species. After discovery in November 2015 in E. coli (strain SHP45) from a pig in China it has been found in Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Enterobacter aerogenes, and Enterobacter cloacae. , it has b
Protein · UniProt
Phosphatidylethanolamine transferase Mcr-1
- Gene
- mcr1
- Organism
- Escherichia coli
- Length
- 541 aa
- Molecular mass
- 60,124 Da
- Evidence
- 1: Evidence at protein level
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A (PubMed:26603172, PubMed:29079699). Phosphoethanolamine modification of lipid A confers polymyxin resistance (PubMed:26603172). Confers resistance to polymyxin-type antibiotics such as colistin; in the E.coli strain W3110 (PubMed:26603172)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- UNKNOWNImpact of Reducing Colistin Use on Colistin Resistance in Humans and Poultry in IndonesiaErasmus Medical Center · NCT05960084
~5 min read
Encyclopedic overview
7 sectionsContents
- Description
- Discovery and geographical spread
- Origins
- Inhibition
- Other ''mcr'' genes
- See also
- References
thumb|right|Escherichia coli|E. coli, the bacterium in which MCR-1 was first identified. The mobilized colistin resistance (mcr) gene confers plasmid-mediated resistance to colistin, one of a number of last-resort antibiotics for treating Gram-negative infections. mcr-1, the original variant, is capable of horizontal transfer between different strains of a bacterial species. After discovery in November 2015 in E. coli (strain SHP45) from a pig in China it has been found in Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Enterobacter aerogenes, and Enterobacter cloacae. , it has been detected in more than 30 countries on 5 continents in less than a year.
==Description== The "mobilized colistin resistance" (mcr-1) gene confers plasmid-mediated resistance to colistin, a polymyxin and one of a number of last-resort antibiotics for treating infections. The gene is found in no less than ten species of the Enterobacteriaceae: Escherichia coli, Salmonella, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Cronobacter sakazakii, Shigella sonnei, Kluyvera species, Citrobacter species, and Raoultella ornithinolytica.
Excerpted from Wikipedia’s “MCR-1” article, available under the CC BY-SA 4.0 licence.