PPP2R1A
Sign in to saveAlso known as PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
In the Vinony graph
Vinony's link graph records 19 inbound references to PPP2R1A, and connects out to PubMed, Ensembl genome database project and enzyme.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 6 Wikipedia language editions.
Gene data
PPP2R1A- Name
- protein phosphatase 2 scaffold subunit Aalpha
- Type
- protein-coding
- Position
- 52,170,936–52,229,518 (+)
- Aliases
- HJS2, MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A
- Ensembl
- ENSG00000105568
- RefSeq RNA
- NM_001363656.2, NM_014225.6, NR_033500.2
- RefSeq protein
- NP_001350585.1, NP_055040.2
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 2 scaffold subunit Aalpha
- Symbol
- PPP2R1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:52,170,936-52,229,518
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PPP2R1A PDB 1b3u.png
Show 7 more facts
- HomoloGene ID
- 68559
- cytogenetic location
- 19q13.41
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5518
- genomic end
- 52229518
- genomic start
- 52190048
- chromosome
- human chromosome 19
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Role in human pathology
- Interactions
- Arabidopsis RCN1
- References
- Further reading
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
== Function == This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
Excerpted from Wikipedia’s “PPP2R1A” article, available under the CC BY-SA 4.0 licence.