PPP2R1A
Sign in to saveAlso known as PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
Gene data
PPP2R1A- Name
- protein phosphatase 2 scaffold subunit Aalpha
- Type
- protein-coding
- Position
- 52,170,936–52,229,518 (+)
- Aliases
- HJS2, MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A
- Ensembl
- ENSG00000105568
- RefSeq RNA
- NM_001363656.2, NM_014225.6, NR_033500.2
- RefSeq protein
- NP_001350585.1, NP_055040.2
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein PPP2R1A PDB 1b3u.png
Show 5 more facts
- HomoloGene ID
- 68559
- cytogenetic location
- 19q13.41
- exact match
- identifiers.org/ncbigene/5518
- genomic end
- 52229518
- genomic start
- 52190048
Sources (4)
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Role in human pathology
- Interactions
- Arabidopsis RCN1
- References
- Further reading
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).
== Function == This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.