PPM1A
Sign in to saveAlso known as PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to PPM1A, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Vinony links it to 6 Wikipedia language editions.
Gene data
PPM1A- Name
- protein phosphatase, Mg2+/Mn2+ dependent 1A
- Type
- protein-coding
- Position
- 60,245,752–60,299,223 (+)
- Aliases
- PP2C-ALPHA, PP2CA, PP2Calpha
- Ensembl
- ENSG00000100614
- RefSeq RNA
- NM_021003.5, NM_177951.3, NM_177952.3, XM_011536881.4, XM_011536883.2
- RefSeq protein
- NP_066283.1, NP_808820.1, NP_808821.2, XP_011535183.1, XP_011535185.1
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase, Mg2+/Mn2+ dependent 1A
- Symbol
- PPM1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:60,245,752-60,299,223
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PPM1A PDB 1a6q.png
Show 8 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 56428
- exact match
- identifiers.org/ncbigene/5494
- genomic end
- 60765805
- genomic start
- 60712470
- chromosome
- human chromosome 14
- cytogenetic location
- 14q23.1
- expressed in
- glutes
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.
Excerpted from Wikipedia’s “PPM1A” article, available under the CC BY-SA 4.0 licence.