PRIM2
Sign in to saveAlso known as PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
DNA primase large subunit in humans is encoded by the PRIM2 gene and is part of the enzyme DNA polymerase alpha.
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Vinony's link graph records 466 inbound references to PRIM2, and connects out to DNA replication, PubMed and DNA polymerase.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 6 Wikipedia language editions.
Gene data
PRIM2- Name
- DNA primase subunit 2
- Type
- protein-coding
- Position
- 57,221,513–57,647,924 (+)
- Aliases
- PRIM2A, p58
- Ensembl
- ENSG00000146143
- RefSeq RNA
- NM_000947.5, NM_001282487.2, NM_001282488.2, XM_047418987.1, XM_047418988.1
- RefSeq protein
- NP_000938.2, NP_001269416.1, NP_001269417.1, XP_047274943.1, XP_047274944.1
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DNA primase subunit 2
- Symbol
- PRIM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:57,221,513-57,647,924
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 731
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5558
- chromosome
- human chromosome 6
- genomic start
- 57179603
- genomic end
- 57646850
- cytogenetic location
- 6p11.2
- expressed in
- rectum
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
DNA primase large subunit in humans is encoded by the PRIM2 gene and is part of the enzyme DNA polymerase alpha.
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.
Excerpted from Wikipedia’s “PRIM2” article, available under the CC BY-SA 4.0 licence.
Available in 6 languages
via Wikidata sitelinks · CC0