propentofylline

Chemical data

Formula

C15H22N4O3

Molecular weight

306.36 g/mol

IUPAC name

3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione

SMILES

CCCN1C=NC2=C1C(=O)N(C(=O)N2C)CCCCC(=O)C

InChIKey

RBQOQRRFDPXAGN-UHFFFAOYSA-N

XLogP

0.7

Polar surface area

75.5 Ų

H-bond donors

0

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Phase 2

Molecule type

Small molecule

Indications

attention deficit hyperactivity disorder

via ChEMBL · EBI

• Propentofylline for dementia.The Cochrane database of systematic reviews · 2003
• Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain.Handbook of experimental pharmacology · 2011
• Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages.Experimental neurology · 2012
• Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials.Dementia and geriatric cognitive disorders · 1998
• Clinical trials in dementia with propentofylline.Annals of the New York Academy of Sciences · 1997

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

306.169

via Wikidata · CC0