Structure via PubChem · Public domain (PubChem)
propiomazine
Sign in to saveAlso known as CB-1678, WY-1359, 3-propionyl-10-dimethylaminoisopropylphenothiazine, 10-(2-dimethylaminopropyl)-2-propionylphenothiazine, 2-propionyl-10-[2-(dimethylamino)propyl]phenothiazine
Propiomazine, sold under the brand name Propavan among others, is an antihistamine which is used to treat insomnia and to produce sedation and relieve anxiety before or during surgery or other procedures and in combination with analgesics as well as during labor. Propiomazine is a phenothiazine, but is not used therapeutically as a neuroleptic because it does not block dopamine receptors well.
Chemical data
- Formula
- C20H24N2OS
- Molecular weight
- 340.5 g/mol
- IUPAC name
- 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
- SMILES
- CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C
- InChIKey
- UVOIBTBFPOZKGP-UHFFFAOYSA-N
- XLogP
- 4.8
- Polar surface area
- 48.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1960
- Admin. routes
- parenteral
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 340.160934
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₀H₂₄N₂OS
- defined daily dose
- 25.0
- World Health Organisation international non-proprietary name
- propiomazine
- medical condition treated
- insomnia
- canonical SMILES
- CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C
- subject has role
- H1 antagonist
- Commons category
- Propiomazine
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Chemistry
- Society and culture
- Brand names
- Availability
- References
Propiomazine, sold under the brand name Propavan among others, is an antihistamine which is used to treat insomnia and to produce sedation and relieve anxiety before or during surgery or other procedures and in combination with analgesics as well as during labor. Propiomazine is a phenothiazine, but is not used therapeutically as a neuroleptic because it does not block dopamine receptors well.
==Medical uses== Propiomazine has been used in the treatment of insomnia.
Excerpted from Wikipedia’s “propiomazine” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0