77-LH-28-1
Sign in to saveAlso known as CHEMBL3354065, 560085-11-2, GTPL3271, SCHEMBL4100746, DTXSID90437063, PHMGZAICAOYEAF-UHFFFAOYSA-N, BDBM50030196, HE353091
77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M1) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects. It has been used as a lead compound for discovery of other M1 agonists, and a crystal structure of the bound complex between 77-LH-28-1 and the M1 receptor has been published.
Chemical data
- Formula
- C21H32N2O
- Molecular weight
- 328.5 g/mol
- IUPAC name
- 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one
via PubChem
Article
1 sectionsContents
- References
77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M1) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects. It has been used as a lead compound for discovery of other M1 agonists, and a crystal structure of the bound complex between 77-LH-28-1 and the M1 receptor has been published.
== References ==