PTK2

Name

protein tyrosine kinase 2

Type

protein-coding

Position

140,657,900–141,002,216 (−)

Aliases

FADK, FADK 1, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK

Ensembl

ENSG00000169398

RefSeq RNA

NM_001199649.2, NM_001316342.2, NM_001352694.2, NM_001352695.2, NM_001352696.2

RefSeq protein

NP_001186578.1, NP_001303271.1, NP_001339623.1, NP_001339624.1, NP_001339625.1

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].

via MyGene.info

Wikidata facts

Instance of

gene

Image

Protein PTK2 PDB 1k04.png

via Wikidata · CC0