PURA

Also known as PUR-ALPHA, PUR1, PURALPHA, MRD31, purine-rich element binding protein A, purine rich element binding protein A, NEDRIHF

Pur-alpha is a protein that in humans is encoded by the PURA gene located at chromosome 5, band q31.

Gene data

PURA

Name: purine rich element binding protein A
Type: protein-coding
Position: 140,107,777–140,125,619 (+)
Aliases: MRD31, NEDRIHF, PUR-ALPHA, PUR1, PURALPHA
Ensembl: ENSG00000185129
RefSeq RNA: NM_005859.5
RefSeq protein: NP_005850.1

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II DNA replication initiation regulation of transcription by RNA polymerase II negative regulation of translation dendritic transport of messenger ribonucleoprotein complex

Molecular function

mRNA regulatory element binding translation repressor activity mRNA regulatory element binding translation repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding

Cellular component

chromosome, telomeric region nucleus nucleus nucleus nucleus cytoplasm dendrite neuronal cell body

Pathways

Exercise-induced Circadian Regulation

via MyGene.info

Gene · Ensembl

purine rich element binding protein A

Symbol: PURA
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:140,107,777-140,125,619
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4279
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5813
genomic end: 139496321
genomic start: 139487362
chromosome: human chromosome 5
cytogenetic location: 5q31.3
expressed in: pons

Sources (5)

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~9 min read

Encyclopedic overview

10 sections

Contents

Evolutionary conservation and function
Relevance in human diseases
Genetic perturbation in leukemia and anti-proliferative effect
Role in mammalian brain development and neurological diseases
Influence on HIV-1 replication
Cooperative effect with HIV-1 on JC polyomavirus replication and expression
Role in amyotrophic lateral sclerosis (ALS)
Notes
References
Further reading

Pur-alpha is a protein that in humans is encoded by the PURA gene located at chromosome 5, band q31.

Pur-alpha is an ancient, multi-functional DNA- and RNA-binding protein. PURA is expressed in every human tissue, where it exists as a protein of 322 amino acids. According to convention, PURA, the gene, is written italicized in all upper case letters. Pur-alpha, the protein, is written with the first letter capitalized and can be found listed as Pur-alpha, Pur-α, Pura, Puralpha, Pur alpha and Pur1.

Excerpted from Wikipedia’s “PURA” article, available under the CC BY-SA 4.0 licence.

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