Structure via PubChem · Public domain (PubChem)
pyriminil
Sign in to savePyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.
Chemical data
- Formula
- C13H12N4O3
- Molecular weight
- 272.26 g/mol
- IUPAC name
- 1-(4-nitrophenyl)-3-(pyridin-3-ylmethyl)urea
- SMILES
- C1=CC(=CN=C1)CNC(=O)NC2=CC=C(C=C2)[N+](=O)[O-]
- InChIKey
- CLKZWXHKFXZIMA-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 99.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
51 papers- Trials of the rodenticide pyriminil against wild house mice (Mus musculus L.).The Journal of hygiene · 1978
- PNU intoxication.American journal of diseases of children (1960) · 1980
- The "sniffing bar".Annals of emergency medicine · 1983
- Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.eLife · 2021
- [Diabetes due to PNU (rat poison)].Harefuah · 1980
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 272.091
- Has use
- rodenticide
Show 3 more facts
- chemical formula
- C₁₃H₁₂N₄O₃
- canonical SMILES
- C1=CC(=CN=C1)CNC(=O)NC2=CC=C(C=C2)[N+](=O)[O-]
- Commons category
- Pyrinuron
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.
==References==
Excerpted from Wikipedia’s “pyriminil” article, available under the CC BY-SA 4.0 licence.