RANBP1
Sign in to saveAlso known as HTF9A, RAN binding protein 1
Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.
Gene data
RANBP1- Name
- RAN binding protein 1
- Type
- protein-coding
- Aliases
- HTF9A
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
via MyGene.info
Wikidata facts
- Image
- Protein RANBP1 PDB 1k5d.png
Show 5 more facts
- HomoloGene ID
- 21600
- exact match
- identifiers.org/ncbigene/5902
- genomic end
- 20127355
- genomic start
- 20103461
- cytogenetic location
- 22q11.21
Sources (4)
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Article
3 sectionsContents
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- Further reading
Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.